metapredict online · v3.0.1

metapredict oneline (V3)

metapredict is a deep-learning consensus predictor of intrinsic disorder. Paste a sequence below, then drag across the plot to pull any region straight onto your clipboard.

Examples:
IDR definition settings

These control how the continuous disorder profile is carved into discrete IDRs. Leave the threshold blank to use whatever the selected network was calibrated with (V1 = 0.42, V2 and V3 = 0.5). Changing any of these re-runs the prediction.

Notes

One sequence at a time

metapredict.net handles a single sequence per request. For anything bigger you have two good options:

Which network should I use?

V3 is the default and the one to use for new work — it is our most accurate predictor (See Lotthammer et al. bioRxiv). V2 and V1 are kept available so older analyses can be reproduced exactly; V1 in particular uses a different disorder threshold (0.42) and will give noticeably different IDR boundaries.

More conformational properties

The selection panel reports ALBATROSS predictions for the region you have highlighted. If you want the full set of ensemble properties, head to the ALBATROSS Colab notebook.

How to cite

Metapredict enables accurate disorder prediction across the Tree of Life Lotthammer, J. M., Hernández-García, J., Griffith, D., Weijers, D., Holehouse, A. S.*, Emenecker, R. J.* — bioRxiv (2024)
Metapredict: a fast, accurate, and easy-to-use predictor of consensus disorder and structure Emenecker, R. J., Griffith, D., & Holehouse, A. S. (2021). Biophysical Journal 120(20), 4312–4319. Link
Direct prediction of intrinsically disordered protein conformational properties from sequence Lotthammer, J. M.*, Ginell, G. M.*, Griffith, D.*, Emenecker, R. J. & Holehouse, A. S. (2024). Nature Methods 21, 465–476. Link

Cite the ALBATROSS paper if you use the predicted dimensions in the selection panel.

Changelog

Recent changes to metapredict.net

July 2026

  • Rebuilt the site around an interactive viewer: drag to select a region and it is copied to your clipboard automatically.
  • Added a drop-down to run any of the metapredict disorder networks (V1, V2, V3) and either pLDDT network.
  • Per-selection sequence and ALBATROSS conformational properties.
  • Sequence view with chemistry or disorder colouring, plus UniProt accession lookup.
  • Plots now export as PNG or vector SVG; scores export includes an IDR flag column.

November 5th 2024

  • metapredict V3 became the default disorder predictor.

October 22nd 2023

  • Improved input parsing; added AFRC-normalised Rg and Re per IDR.

May 31st 2023

  • Updated the ALBATROSS networks to version 2.

May 8th 2023

  • Added predicted radius of gyration and end-to-end distance from ALBATROSS.

August 27th 2022

  • Improved stability with non-standard amino acids; added the Colab notebook link.

March 15th 2022

  • Back-end updated to metapredict V2; IDRs shaded on plots.